The bench Top Lyophilizers is to freeze the material containing a large amount of water in advance into a solid, and then make the water vapor directly sublime from the solid under a certain vacuum condition, and the material itself remains in the ice shelf when it is frozen, so It has the same volume after drying and is loose and porous. The ice absorbs heat during sublimation, causing the temperature of the product itself to drop and slowing down the sublimation speed. In order to increase the sublimation speed and shorten the drying time, the product must be properly heated. The entire drying process is carried out at a lower temperature. The whole machine is small in structure, simple and applicable, and flexible. It can be used in a variety of applications such as colleges and universities, scientific research laboratories, etc., and can meet the freeze-drying needs of most laboratories and the exploration of product technology.
bench Top Lyophilizers is mainly composed of drying box, vacuum system, refrigeration system, cold trap system, heating system, capping system, automatic control system, etc. The implementation of GMP standard, achieve a high degree of sterilization, dust-free, achieve high reliability, safety, and easy maintenance. For this reason, bench Top Lyophilizerss often use a steam sterilization system (SIP) to ensure complete sterilization and no dead ends. At the same time, supplemented by the cleaning-in-place system (CIP), the drying chamber, condenser, main valve and pipeline are cleaned in situ to preset the discharge slope to ensure no liquid retention.
The operation of bench Top Lyophilizers:
1. Before starting each time, check whether the pump oil in the vacuum pump is sufficient.
2. Unscrew the drain valve to let the remaining water flow out. Tighten the valve after draining.
3. Check whether the contact part of the freeze-drying chamber and the cold trap is intact, clean and readjust if necessary.
4. Close all valves (valves directly connected to the freeze-dried bottle, the white knob is up to close). Close the valve connecting the cold trap and the vacuum pump (behind the bench Top Lyophilizers, connected to the vacuum tube).
5. Turn on the power switch of the cold trap and turn on the power switch of the vacuum pump.
After 6.15 minutes, open the valve connecting the cold trap to the vacuum pump.
After 7.1 minutes, the pre-frozen sample (already in the freeze-drying bottle) can be hung on the holder, and the corresponding valve can be opened to start the freeze-drying process.
8. After the freeze-drying is finished, close the corresponding valve (white knob upwards), and remove the freeze-drying bottle.
9. After all the freeze-dried bottles are removed, turn off the vacuum pump power supply and the cold trap power supply in turn.
10. After the frost in the cold trap has melted, open the drain valve to drain, and then turn off the power of the bench Top Lyophilizers